Funding
Back to listing

JPND Call for Multinational research projects for Pathway Analysis across Neurodegenerative Diseases

Background

JPND is a trans-national initiative that aims to address the growing societal challenge presented by age-related neurodegenerative diseases. It involves research funders from 30 member countries. Spanning biomedical, healthcare and social science research, JPND aims to increase coordinated investment between participating countries in research aimed at finding causes, developing cures, and identifying appropriate ways to care for those with neurodegenerative diseases. MRC is leading on JPND activity for the UK. 

There is clinical, genetic and biochemical evidence that similar molecular pathways are relevant in different neurodegenerative and other chronic diseases.  This JPND call is for multidisciplinary proposals to perform network analyses across such diseases and to elucidate the underlying mechanisms involved.

Aims

The aim of the call is to establish a limited number of ambitious, innovative, multi-national and multi-disciplinary collaborative research projects that

  • combine experimental approaches from fundamental, pre-clinical and/or clinical research
  • perform network analyses in different neurodegenerative and/or other chronic diseases to elucidate the underlying common and differing mechanisms between the investigated diseases
  • add value to existing research by analysing diseases across traditional clinical boundaries, technologies and disciplines, thereby gaining deeper understanding of the patho-physiological mechanisms of neurodegenerative diseases.

The following neurodegenerative diseases are included in the call: Alzheimer’s disease and other dementias, Parkinson’s disease and PDÔÇÉrelated disorders, prion diseases, motor neuron diseases, Huntington’s disease, spinocerebellar ataxia (SCA) and spinal muscular atrophy (SMA). Cross-disease analysis may solely comprise different neurodegenerative diseases or include other chronic diseases (e.g. chronic mental or physical disorders).

Applications

Up to six research groups from at least three different countries may collaborate within a consortium. Proposals should have novel, ambitious aims and ideas combined with well-structured work plans and clearly defined goals deliverable within three years. Appropriate access to relevant patient populations or biomaterial collections must be demonstrated, as well as plans for patient, carer and public involvement. The impact on disease understanding or future development of treatments for neurodegenerative diseases should be explicitly stated in the application. Where it adds value, proposals are encouraged to involve training of young researchers and import expertise from areas outside of neurodegeneration research that can bring innovation to the approach.

The total funding available for this call is nearly 23 million euro (from 22 participating countries). JPND awards made through this call will be funded through national agencies supporting the relevant components of collaborative projects. For UK-based activity, this funding will be provided by the MRC through the Neurosciences and Mental Health Board which has 2.3 million euro available to support successful UK groups. MRC anticipates that this sum will be able to provide substantive support for the involvement of UK groups in 3-5 trans-national awards.

The call and associated peer review will be administered through a central JPND process, with MRC representation throughout. The call has a two-step procedure, with a first stage (pre-proposal submission) deadline of 23:39h C.E.T. on March 6th 2017.  Applicants will later be advised if they may submit a full proposal, the deadline for which will be 23:59h C.E.T. on June 28th 2017. Funding decisions will be communicated by the end of October 2017.

Contacts

Please address any MRC queries to:

Dr Catherine Moody Programme Manager for Neurodegenerative Diseases or Dr Louise Richards, Science Manager for Neurodegenerative Diseases

Email: jpndpathways2017@headoffice.mrc.ac.uk

Information is also available from the JPND Joint Call Secretariat:

Dr. Thomas Becker
thomas.becker@dlr.de
(+49) 228-3821 1686

Dr. Sabrina Voß
sabrina.voss@dlr.de
(+49) 228-3821 1821

More detailed information on criteria and applications is available on the JPND website. This includes specific requirements for UK researchers.