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MRC/AstraZeneca: Mechanisms of Disease Call assets

Full list of compounds:

Please click the AZ code for further compound information.

 

Compound details

Pre-Development code

AZ code & further information

Mechanism of Action

Original development indication

Type of proposals invited

AZ10353926

AZD0530 (Saracatinib)

SRC Tyrosine Kinase Inhibitor

Solid tumour

Pre-clinical & Clinical

AZ12272852

AZD1236

Matrix Metallopeptidase (MMP) 9|12 Inhibitor

Chronic Obstructive Pulmonary Disease

Pre-clinical & Clinical

AZ12501796

AZD1656

Glucokinase Activator

Diabetes and Obesity

Pre-clinical & Clinical

AZ12472520

AZD2624

Neurokinin Receptor NK3 Antagonist

Schizophrenia

Pre-clinical & Clinical

AZ11941831

AZD3355

GABABR1 Receptor Agonist

Gastroesophageal Reflux Disease

Pre-clinical & Clinical

AZ12647468

AZD4017

11-beta Hydroxysteroid Dehydrogenase Type1Inhibitor

Diabetes, ophthalmology

Pre-clinical & Clinical

AZ11922817

ZD4054 (Zibotentan)

Endothelin A Receptor Antagonist

Prostate cancer

Pre-clinical & Clinical

AZ11938919

AZD5904

Myeloperoxidase inhibitor

Chronic Obstructive Pulmonary Disease

Pre-clinical & Clinical

AZ12466186

AZD7325

GABAA Ion Channel Stimulator

Anxiety

Pre-clinical & Clinical

AZ12484348

AZD8529

Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator

Schizophrenia

Pre-clinical & Clinical

AZ11548415

AZD1080

GSK3b Inhibitor

Alzheimer’s

Pre-clinical

AZ12457709

AZD1386

TRPV1 Ion channel Inhibitor

Analgesia, Gastroesophageal Reflux Disease

Pre-clinical

AZ12543168

AZD1704

Cannabinoid CB1 receptor Agonist

Analgesia

Pre-clinical

AZ11942571

AZD4619

PPARA Agonist

Dyslipidaemia

Pre-clinical

AZ12096971

AZD4769

EGFR Tyrosine Kinase Inhibitor

Solid tumour

Pre-clinical

AZ12677524

AZD6088

Muscarinic M1 Receptor Agonist

Analgesia

Pre-clinical

AZ11920155

AZD6605

Matrix Metallopeptidase (MMP) 13 Inhibitor

Osteoarthritis

Pre-clinical

AZ12012199

AZD6703

MAPK14 (p38) tyrosine kinase inhibitor

Rheumatoid arthritis

Pre-clinical

AZ12488024

AZD7268

δ-Opioid receptor agonist

Depression and anxiety disorders

Pre-clinical

AZ12877733

AZD7687

DGAT Inhibitor

Diabetes

Pre-clinical

AZ12600000

AZD8055

mTOR Serine/Threonine Kinase (mTORC1/2) Inhibitor

Solid Tumour

Pre-clinical

n/a

n/a

P2X7 ion channel inhibitor

Probe molecule to investigate the biology of the P2X7 ion channel

Pre-clinical

 

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