Professor Pamela Shaw
MRC bodies you are a member of:
- NMHB
Main form of employment:
- University of Sheffield
Research group/department web page/s:
Personal remuneration:
- Consultancy for Biogen Idec, Sanofi-Aventis, Ono Pharma
Shareholdings and financial interests in companies
- None
Research income during current session [over £50k per grant]
- MOTOR NEURONE DISEASE ASSOCIATION 2008·2012 PhD Studentship (£78,618). Mitochondrial redox dysfunction in MND: a therapeutic role for the peroxiredoxins. Jointly with Dr C Wood-Allum.
- MOTOR NEURONE DISEASE ASSOCIATION 2008 - 2012 (£159,817) Sheffield Care and Research Centre for Motor Neuron Disorders Programme grant.
- EUROPEAN UNION FRAMEWORK 7: 2008 ·2012 Sheffield component (£797,000). Mitochondrial dysfunction in neurodegenerative diseases: towards new therapeutics. Mitotarget Consortium. Joint PI PJ Shaw and AJ Grierson.
- MOTOR NEURONE DISEASE ASSOCIATION 2008 ·2012 £168,068. Evaluation of the impact of a cough-assist mechanical in-exsufflator (MI·E) device on morbidity, quality of life and survival in patients with motor neurone disease (MND) using non-invasive ventilation (NIV). PI.
- MEDICAL RESEARCH COUNCIL Centre for Developmental and Biomedical Genetics Fellowship Award 2008-2012 (- £200K). Investigation of the role of TDP43 mutations in motor neuron injury. Clinical Training Fellowship for Dr Channa Hewamadduma. PI jointly with Dr Andrew Grierson and Professor Philip Ingham.
- DEPARTMENT OF HEALTH NIHR CLINICAL RESEARCH NETWORK FOR DEMENTIAS AND NEURODEGENERATIVE DISEASES (DeNDroN) 2006 -2011 (£1,041,280). Supplementary resources for Motor Neuron Disease and Huntington's disease. 2006 -2011
- MEDICAL RESEARCH COUNCIL CENTRE FOR DEVELOPMENTAL AND BIOMEDICAL GENETICS 2007-2012 £2,383,148 PI Prof. Philip Ingham. PJ Shaw is one of 12 named co-applicants.
- MEDICAL RESEARCH COUNCIL MOTOR NEURONE DISEASE ASSOCIATION 2008 -2012 (£531,772) TDP-43 and alternative splicing in motor neurone disease. Clinical Training Fellowship for Dr Robin Highley. Jointly with Prof Paul Ince and Dr Janine Kirby.
- MOTOR NEURONE DISEASE ASSOCIATION 2008-2012 £378,278 LlCALS A Randomised controlled trial of lithium carbonate in ALS. PI Professor Nigel Leigh King's College Hospital, London.
- MOTOR NEURONE DISEASE ASSOCIATION 2009 - 2013 (£148,058). Creation of a national DNA and cell line repository for genetic research into motor neurone disease Extension Grant. Joint 3 centre programme between Universities of Sheffield, Birmingham and Institute of Psychiatry, King's College, London.
- EPSRC 2009 - 2012 (£2.4million) Engineering virus like nanoparticles for targeting the CNS.Jointly with Dr Guiseppe Battaglia and multiple members of Tissue Engineering, Chemistry and Physics departments.
- MEDICAL RESEARCH COUNCIL MND ASSOCIATION 2009-2012 (£ 232,710) Analysis of physical activity as a risk factor for MND in genetically susceptible individuals. Research training fellowship for Dr Ceryl Moore. PI Jointly with Dr Chris McDermott.
- MOTOR NEURONE DISEASE ASSOCIATION 2009 - 2012 £170,750 Comparison of gene expression profile in two S001 G93A mouse models showing strain specific difference in motor neuron disease phenotype. Jointly with Dr Catenna Bendotti, Mario Negri Institute Milan.
- EU FRAMEWORK 7 HEALTH 2010 TWO STAGE GRANT. 2010 -2015 E8,998,359 (Sheffield component E700,506) or total E927,675 Euromotor: Systems Biology In ALS. PJ Shaw one of 16 PI's.
- SHEFFIELD HOSPITALS CHARITABLE TRUST 2010 -2013 £63,370. A zebrafish model 01 motor neurone disease as a tool for drug screening. Jointly with Dr Tennare Ramesh.
- NIHR HEALTH TECHNOLOGY ASSESSMENT PROGRAMME: Clinical Evaluation and trials. 2010 -2013 £1.472,060 A controlled adjunct trial in patients with respiratory muscle weakness due to motor neurone disease of the NeuRxl4 diaphragm pacing system (DiPALS). Jointly with Dr Chris McDermott.
- MOTOR NEURONE DISEASE ASSOCIATION 2010 -2013 £300,000 A controlled adjunct trial in patients with respiratory muscle weakness due to motor neurone disease of the NeuRx/4 diaphragm pacing system (DiPALS). Jointly with Dr Chris McDermott.
- MOTOR NEURONE DISEASE ASSOCIATION 2010-2012 £162,761 Screening microRNAs as blood based biomarkers for motor neurone disease (MND). PI Jointly with Dr Janine Kirby and Dr Emily Goodall.
- FOUNDATION THEIRRY LATRAN 2010 -2011 €30,000 Utilization 01 features of the eany disease phenotypes in a zebrafish model of ALS for pharmacological screening to detect small molecule neuroprotective compounds. Coapplicant with Tennore Ramesh.
- MOTOR NEURONE DISEASE ASSOCIATION 2011 -2014 £195,000 Identification of progressive neuronal stress from early development to adulthood and utilisation of this readout in a pharmacological screen in the sod1 transgenic zebrafish model of ALSIMND. Jointly with Dr Tennore Ramesh.
- MEDICAL RESEARCH COUNCIL DEVELOPMENTAL PATHWAY FUNDING SCHEME 2010 - 2012 £656,000 SMN replacement therapy for spinal muscular atrophy. Co - applicant with Professor Mimoun Azzouz, Professor Paul Ince and Dr Ke Ning.
- EU FRAMEWORK 7 MARIE CURIE 2012 - 2015 E 271,943 Title: screening of candidate targets for astrocyte toxicity in motor neurone disease. PI Fellowship for Laura Ferraiuolo
- MEDICAL RESEARCH COUNCIL 2012 -2014 £396,130 Oxidative DNA Damage And Transcriptional Impairment In Brain Ageing As An Easy Contributor To Cognitive Impairment. Co-applicant with Dr Stephen Wharton.
- THIERRY LATRAN FONDATION 2012-2014 E 122,000 Role of C90RF72 in proteostasis. K de Vos, AJ Grierson, PJ Shaw.
- MEDICAL RESEARCH COUNCIL 2012-2014 £190,197 Characterisation of biological pathways dysregulated in ALS cases with hexanucleotide expansions of C90RF72. Clinical training Fellowship for Dr Johnathan Cooper-Knock.
- EU JOINT PROGRAMME FOR NEURODEGENERATION I MEDICAL RESEARCH COUNCIL 2012-2015 Sampling and biomarker Optimisation and Harmonisation In ALS and other motor neuron diseases (SOPHIA). PI for UK component.
Major academic collaborators [national and international]
- Professor Ammar al Chalabi King's College London
- Professor Karen Morrison University of Birmingham
- Collaboration with multiple UK and European ALS/MND investigators in relation to the Euromotor and SOPHIA multicentre collaborative grants.
- Collaboration with multiple DeNDRoN investigators and MND Centre Directors in relation to the DIPALS and PROGAS clinical studies.
- Collaboration with Professors Jun Xu, Zhengliang Gao and Zhuyel Nie Tongji University Shanghai, China in relation to iPS derived motor neurons as a model to study the pathophysiology of motor neuron degeneration.
- Collaboration with Professor Brian Kasper Ohio State University, USA in relation to glial pathophysiology in ALS/MND.
Un-remunerated involvement with and membership of medical, bio-medical, pharmaceutical, healthcare provision or science or health policy/communication and similar activities/organisations
- None
Political/pressure group associations:
- None
Family:
- None
