MRC Centre for Developmental and Biomedical Genetics
Professor Philip Ingham
Director of the MRC Centre for Developmental and Biomedical Genetics
The sophisticated genetic tools and techniques established over the past two decades in Drosophila, and more recently in zebrafish, allow developmental and physiological processes to be analysed at cellular and sub-cellular resolution.
The MRC Centre for Developmental and Biomedical Genetics brings together developmental geneticists with clinician scientists, creating a focus of expertise in the development of animal models of human disease with the aim of stimulating the translation of findings from model systems to the development of novel therapies and clinical practice. Models of human disease gene dysfunction are generated using transgenesis and targeted gene inactivation in both species and analysed using a range of approaches. Gene discovery programmes using both forward mutation screening and gene expression profiling are being combined with chemical genetic approaches to identify novel components of developmental pathways and networks and unravel their mechanisms of action. Discoveries made in flies and fish are validated in the chick embryo and using mammalian cell cultures, including embryonic stem cells.
Centre for Developmental and Biomedical Genetics
Department of Biomedical Science
Firth Court
University of Sheffield
Western Bank
Sheffield
S10 2TN
Telephone: +44 (0)114 222 2710
Fax: +44 (0)114 276 5413
Web: cdbg.shef.ac.uk
