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Multiple Sclerosis and Parkinson's Tissue

 

Name of Bank

Multiple Sclerosis and Parkinson’s Tissue Bank

Summary

The bank operates two nationwide prospective donor schemes with a total of approx 10,000 donors. The MSPTB is a valuable source of high quality human CNS samples and has been set up to acquire brain and spinal cord from the entire continuum of multiple sclerosis and Parkinsonian pathologies and to make those samples and associated data available to neuroscientists across the globe in order to facilitate research into these and related neurological conditions. Our collection contains over 120,000 snap-frozen, fixed-frozen/cryoprotected and paraffin-embedded specimens from over 1,400 clinically and neuropathologically well characterised MS, PD and control cases. The Tissue Bank operates an easy and open access policy to tissue and welcomes applications from academic institutions and the biotechnology and biopharm sector.

Primary Contact(s)

Dr Djordje Gveric
Centre for Neuroscience
Hammersmith Hospital, Imperial College
London
W12 0NN
Telephone: 020 7594 7204
Email: d.gveric@imperial.ac.uk

 

Professor Richard Reynolds
Centre for Neuroscience
Hammersmith Hospital, Imperial College
London
W12 0NN
Telephone: 020 7594 6668
Email: r.reynolds@imperial.ac.uk

 

Professor David Dexter
Centre for Neuroscience
Hammersmith Hospital, Imperial College
London
W12 0NN
Telephone: 020 7594 6665
Email:d.dexter@imperial.ac.uk

Available Sample Types

Mainly brain, spinal cord and CSF from multiple sclerosis, Parkinson’s Disease and controls/disease controls. Other tissue samples (muscle, dorsal root ganglia, etc…) are available for some of the cases.

Snap-frozen, cryoprotected (sucrose) and fixed frozen and formalin fixed/paraffin embedded tissue blocks. Aliquots of frozen cerebrospinal fluid. Whole formalin fixed brains and brain slices (MS, PD and controls/disease controls).

Sample Derivatives

DNA is available for a majority of MS, PD and control cases.

Disease types/subtypes available

MS – primary and secondary progressive and relapsing-remitting forms

PD – idiopathic Parkinson’s disease, PD with dementia, multiple systems atrophy, progressive supranuclear palsy, corticobasal degeneration and dementia with Lewy bodies

Sources of Sample Annotation

MS: GP and neurology notes including medical history and treatments, MSIS-32 and health questionnaires. Full neuropathology report.

PD: GP and neurology notes including medical history and treatments, exhaustive health, lifestyle and follow up questionnaires. Full neuropathology report.

Funding Bodies

Multiple Sclerosis Society of Great Britain and Northern Ireland and Parkinson’s UK

Additional Information

Multiple Sclerosis - www.ukmstissuebank.imperial.ac.uk

Parkinson's - www.parkinsonstissuebank.org.uk

 

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