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MCMB programme

 

As well as supporting medically relevant research across the full spectrum of basic molecular and cellular sciences, the board has a special role in identifying and delivering – often with co-funding - the generic infrastructures that underpin many other areas of basic and translational medical research. These include:

  • The Mary Lyon Centre: national facility for mouse functional genomics, providing world-class expertise, tools and space to generate mouse models of human disease
  • MRC Biomedical NMR Centre, London: national facility for liquid-state NMR studies of biological macromolecules;
  • The UK DNA Banking network: providing resources for research in: acute leukaemia; asthma and eczema; late onset Alzheimer’s disease; breast cancer; colorectal cancer; coronary artery disease; glomerulonephritis; hypertension; age-related macular degeneration; multiple sclerosis; Parkinson’s disease; type 2 diabetes; unipolar depression;
  • The UK Stem Cell Bank: responsible for storing, characterising and supplying ethically-approved, quality-controlled stem cell lines for medical research and treatment.
  • Human Developmental Biology resource: provides tissue resources to researchers studying early human development;
  • Research Complex at Harwell and linked protein production facility (OFFP UK);
  • DIAMOND light source: UK national synchrotron facility which generates beams of light, from infra-red to X-rays, which are used in a wide range of applications, from structural biology through fundamental physics and chemistry to cultural heritage;
  • European Bioinformatics Institute: a centre for research and services in bioinformatics, managing databases of biological data including nucleic acid, protein sequences and macromolecular structures;
  • UK Biobank: a prospective cohort initiative of 500,000 people in the UK between the ages of 40-69 to investigate the effects of lifestyle, environment and genetics on health;
  • ALSPAC: The Avon Longitudinal Study of Parents and Children cohort is designed to understand the ways in which the physical and social environment interact, over time, with the genotype to affect health, behaviour and development;
  • The British 1958 Birth cohort (the National Child Development Study): studies into health and development throughout the lifespan of all those living in Great Britain who were born in one particular week in 1958.
  • HTS HUBS: four HTS Hubs with technical and bioinformatics support, facilitating access to cutting-edge equipment and dedicated technical and bioinformatics expertise.

 

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MCMB priorities

The board has primary responsibility for the MRC’s Stem Cell initiative, including strategic funding for new translational initiatives, regenerative medicine and tissue engineering.

The board has identified a number of research areas for priority investment and wishes to encourage high-quality proposals:

 

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MRC research centres supported by MCMB

Major molecular and cellular medicine research programmes are being carried out in the MRC Clinical Sciences Centre, London, the MRC Laboratory of Molecular Biology, Cambridge and the MRC National Institute for Medical Research, London.

 

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