MRC/AstraZeneca: Mechanisms of Disease Call assets
Full list of compounds:
Please click the AZ code for further compound information.
Compound details
Pre-Development code |
AZ code & further information |
Mechanism of Action |
Original development indication |
Type of proposals invited |
AZ10353926 |
AZD0530 (Saracatinib) |
SRC Tyrosine Kinase Inhibitor |
Solid tumour |
Pre-clinical & Clinical |
AZ12272852 |
Matrix Metallopeptidase (MMP) 9|12 Inhibitor |
Chronic Obstructive Pulmonary Disease |
Pre-clinical & Clinical | |
AZ12501796 |
Glucokinase Activator |
Diabetes and Obesity |
Pre-clinical & Clinical | |
AZ12472520 |
Neurokinin Receptor NK3 Antagonist |
Schizophrenia |
Pre-clinical & Clinical | |
AZ11941831 |
GABABR1 Receptor Agonist |
Gastroesophageal Reflux Disease |
Pre-clinical & Clinical | |
AZ12647468 |
11-beta Hydroxysteroid Dehydrogenase Type1Inhibitor |
Diabetes, ophthalmology |
Pre-clinical & Clinical | |
AZ11922817 |
ZD4054 (Zibotentan) |
Endothelin A Receptor Antagonist |
Prostate cancer |
Pre-clinical & Clinical |
AZ11938919 |
Myeloperoxidase inhibitor |
Chronic Obstructive Pulmonary Disease |
Pre-clinical & Clinical | |
AZ12466186 |
GABAA Ion Channel Stimulator |
Anxiety |
Pre-clinical & Clinical | |
AZ12484348 |
Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator |
Schizophrenia |
Pre-clinical & Clinical | |
AZ11548415 |
GSK3b Inhibitor |
Alzheimer’s |
Pre-clinical | |
AZ12457709 |
TRPV1 Ion channel Inhibitor |
Analgesia, Gastroesophageal Reflux Disease |
Pre-clinical | |
AZ12543168 |
Cannabinoid CB1 receptor Agonist |
Analgesia |
Pre-clinical | |
AZ11942571 |
PPARA Agonist |
Dyslipidaemia |
Pre-clinical | |
AZ12096971 |
EGFR Tyrosine Kinase Inhibitor |
Solid tumour |
Pre-clinical | |
AZ12677524 |
Muscarinic M1 Receptor Agonist |
Analgesia |
Pre-clinical | |
AZ11920155 |
Matrix Metallopeptidase (MMP) 13 Inhibitor |
Osteoarthritis |
Pre-clinical | |
AZ12012199 |
MAPK14 (p38) tyrosine kinase inhibitor |
Rheumatoid arthritis |
Pre-clinical | |
AZ12488024 |
δ-Opioid receptor agonist |
Depression and anxiety disorders |
Pre-clinical | |
AZ12877733 |
DGAT Inhibitor |
Diabetes |
Pre-clinical | |
AZ12600000 |
mTOR Serine/Threonine Kinase (mTORC1/2) Inhibitor |
Solid Tumour |
Pre-clinical | |
n/a |
n/a |
Probe molecule to investigate the biology of the P2X7 ion channel |
Pre-clinical |