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Global Alliance for Chronic Diseases (GACD) - Call for research proposals: prevention and treatment of type 2 diabetes

Call focus: implementation science research

Regional focus: low- and middle-income countries

The Medical Research Council, in partnership with the Global Alliance for Chronic Diseases (GACD), is seeking to generate new knowledge on interventions and their implementation for the prevention and treatment of type 2 diabetes in low- and middle-income countries (LMIC).

The MRC will invest up to 2m. This amount is expected to fund several awards.

Outline Proposals must be submitted via the Je-S system by 4pm on Tuesday, 11th February 2014.

 

Background

In the past twenty years the global death rate from diabetes has doubled and the World Health Organization (WHO) is predicting that this will increase by two thirds by 2030. It is currently estimated that 347 million people worldwide suffer from diabetes, with more than 80% living in low-and middle-income countries. Of those suffering from diabetes, type 2 comprises 90% of this population around the world. Halting the rise in prevalence of diabetes has been identified as one of the 9 WHO NCD global voluntary targets to be met by Member States by 2025.

 

With the burden of this chronic non-communicable disease ever-increasing the Global Alliance for Chronic Diseases (GACD) partnership has agreed to launch a call for proposals on the prevention and treatment of type 2 diabetes, with a focus on implementation and intervention research in low- and middle-income countries. The emphasis of this initiative is on existing approaches to prevention and control of type 2 diabetes rather than development of new treatments.

Aim

The aim of this call is to fund projects that will generate new knowledge on interventions and their implementation for the prevention and treatment of type 2 diabetes in low- and middle-income countries (LMIC), as defined by The World Bank.

 

The GACD partnership is therefore looking for projects that focus on the guiding principles of:

 

  • Reducing health inequalities and inequities in the prevention and treatment of type 2 diabetes in both a local and global context.
  • Pursuing knowledge translation and exchange approaches that are designed to maximize the public health benefits of research findings within different health contexts.
  • Providing evidence to inform local health service providers, policy and decision makers on the effective scaling up of the interventions at the local, national and regional level.

 

Through the launch of a global call the GACD aims to develop a global network of researchers that can enhance the cumulative learning across the individual projects, and work towards understanding how socio-economic, cultural, geopolitical and policy contexts have influenced results and how findings might be adapted and applied in different settings.

 

The funded researchers will form part of a Joint Technical Steering Committee which will meet annually to discuss their research and share information in order to develop approaches to standardise data collection, and wherever feasible to use these standardised approaches in their respective projects.

Scope

Researchers responding to this call can focus on a wide range of prevention and/or treatment strategies. This might include programmes addressing (one or combinations of):

 

  • Lifestyle and behavioural issues such as what changes can be made to provide an environment that supports and promotes better health. This might include community-wide approaches, or other strategies targeting individuals at high-risk. For instance, population prevention strategies designed to address unhealthy diets and physical inactivity as risk factors for diabetes.
  • Structural interventions or policies designed to promote improved health outcomes. For instance, evaluating the contribution of public policies to diabetes prevention efforts, or monitoring the potential effects of such policies if adopted and implemented.
  • Delivery of relevant health care and health interventions.
  • Approaches to implementing accessibility of or adherence to, pharmaceutical, nutritional or other promising or proven interventions.

 

Researchers with ideas that do not fall within these categories are encouraged to contact the Programme Manager for Global Health Strategy (contact details below) to discuss whether their research idea fits the aims and scope of the call.

 

This call is focused on implementation research, to examine what works, for whom and under what contextual circumstances, and how interventions can be adapted and scaled up in ways that are accessible and equitable.

 

Proposals can address prevention or treatment of specific complications of type 2 diabetes. Applicants must justify clearly in their proposal why their chosen topic fits within the aims and scope of this call.

 

Projects addressing gestational diabetes are within the scope of this call.

 

Projects can focus on specific societal groups but a clear justification should be provided as to why the group has been chosen and how the choice will assist the funders in delivering their aim to address health inequities at a local and/or global level.

 

This call is focused on implementation research into interventions for prevention and treatment of type 2 diabetes that are applicable in low resource settings. However, in some settings, the project may need to incorporate work to establish baseline data on the prevalence of diabetes and its risk factors to evaluate the impact of the intervention. Research into these aspects can be incorporated into the proposed work if it does not duplicate existing evidence available.

 

The following types of projects DO NOT fall within the scope of this call:

 

  • Replication of effectiveness studies and clinical trials testing the efficacy or effectiveness of new or established pharmacological agents (or combination of agents) which have wider effects than those relating to type 2 diabetes.
  • Aetiological work, mechanistic, or epidemiological research, which is not part of a wider study to develop implementation science approaches.
  • Phase I or Phase IIa trials.

Eligibility

This GACD call funds partnership working between UK researchers and researchers based in low and/or middle income countries.

 

The Principal Investigators applying for this call must be hosted by a UK institution which is eligible for UK Medical Research Council funding.

 

All projects submitted must include co-investigators from the from the low or middle income country (ies) where the work will take place.

 

It is not permitted for the same person to be Principal Investigator on more than one proposal submitted to this call.

 

Full eligibility details can be found here: GACD Guidance: How to apply

Funding availability

The MRC will make up to 2m available for this scheme and would expect to use this amount to fund several projects.

How to apply

Outline Proposals must be submitted via the Je-S system by 4pm on Tuesday, 11th February 2014.

 

Full details on how to apply to this scheme can be found here:
GACD Guidance: How to apply

 

Please refer queries to Alex Harris:
mrc.gacd@headoffice.mrc.ac.uk

 

If your query relates to whether the topic of your proposal fits the remit of this funding scheme, please contact Jill Jones, Programme Manager for Global Health Strategy:

 

Tel: +44 (0) 20 7395 2207

Email: jill.jones@headoffice.mrc.ac.uk and
Cc: mrc.gacd@headoffice.mrc.ac.uk

 

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