New 3D imaging technique will aid research into gene function
Optical Projection Tomography (OPT) works by taking images of tissue from many different angles. A computer then processes this information and builds up high-resolution 3D images. The efficiency and low expense of OPT should make it feasible to generate complex 3-D ‘maps’ of the genome showing where genes are active, the first step to understanding their functions. The technique will be used initially to aid research on the mouse genome, the results of which will help understand similar gene function in humans. The technique could also be used to speed up and improve the accuracy of medical diagnosis using tissue biopsies from patients. The technique was developed by the MRC Human Genetics Unit in Edinburgh.
Science 2002; 296: 541-545